This article attempts to demonstrate and analyze the rapidly rising numbers of women and girls with HIV/AIDS in African nations. It sets out different steps that can be taken to ensure the protection of young women and girls from the disease, particularly the role the US might play in slowing down or halting the epidemic. The author focuses on sexual violence as a means of spreading the disease, and the lack of economic independence that frequently leads to commercial sex, in which the women and girls are ill-equipped to negotiate for condom use.