This article discusses the Organization of Islamic Cooperation’s (OIC) engagement with the international human rights legislation (IHRL) framework. The OIC is the world’s second-largest intergovernmental organization and the only one unified around a single religion. Several of its human rights declarations justify restricting women’s rights by invoking the supremacy of Islamic law and norms. Blitt argues that failing to reject the OCI’s parochial, Islamic notions of equality and non-discrimination risks undermining the spirit of universality reflected in IHRL ideas of fundamental human freedom and equality in dignity and rights. More immediately, it legitimizes ongoing rights violations against women. Given the OIC’s reach in the Muslim world, these concerns potentially impugn the rights of large swaths of women around the world. Understanding the challenges that Islamic and other religious organizations have posed towards actualizing the IHRL framework will be key to ensuring its global effectiveness and harmony with cultural antecedents.