This article discusses the African Commission on Human and People’s Rights’ adoption in 2014 of General Comment No 2 to interpret provisions of Article 14 of the Protocol to the African Charter on the Rights of Women in Africa. The provisions are related to women’s rights to fertility control, contraception, family planning, information, education, and abortion. The General Comment No 2 goes beyond merely providing states with guidance for framing their domestic laws and also educates healthcare providers, lawyers, policymakers, and judicial officers about the pertinent jurisprudence. The article discusses how the General Comment is particularly helpful because of its emphasis on state obligations to respect, protect, promote, and fulfil their rights guaranteed to women by the Protocol. The article also notes the significance of the fact that the General Comment reflects the WHO definition of a holistic conception of health and the benefits that result from this approach.