This paper focuses on women workers in global supply chains in poor countries, addressing the issue of systemic risks to women’s general health and violations of their health rights. The authors argue that the gender-blind approach of Occupational Safety and Health (OSH) strategies render these women workers vulnerable to serious health risks, rooted in a lack of access to healthcare, poor workplace healthcare, and poor sanitary conditions at work. The current application of OSH standards emphasizes safety inputs but overlooks these broader workplace-related health issues. The authors contend that this failure to align public health standards with international human rights standards leads to long-term harms. They forward a holistic approach to women workers’ right to health that abandons the division between occupational health and general health and assigns responsibility thereto to corporations. They recommend that the United Nations Guiding Principles on Business and Human Rights develop a defined gender approach, so that corporations can adopt an expansive vision of the right to health for women workers in global supply chains.